Shenzhen Institute of Synthetic Biology (iSynBio)
Gaowen Liu Lab
Aneuploidy in Genome Plasticity and Adaptive Evolution
Decoding Genomic Robustness & Evolutionary Trajectories
Based at the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, our laboratory addresses a fundamental biological paradox: how cells adapt and persist across catastrophic genomic crises. By pairing high-throughput robotic pipeline acceleration with deep single-cell spatial-temporal transcriptomics, quantitative lipidomics, and multi-channel fluorescent time-lapse microscopy, we chart structural and biochemical trade-offs at single-cell resolution.
High-Throughput Robotic Pipeline
Automated Micro-Screening and Robotics
By establishing software-driven liquid handling workflows alongside comprehensive screen matrices, we process thousands of variant configurations concurrently to capture real-time adaptive transitions.
Our robotic pipetting architectures allow automated scheduling, environmental control, and precision plate manipulation. This pipeline dramatically accelerates experimental turnaround and minimizes error profiles across deep phenotypic sweeps.
Dynamic Mating & Meiotic Tracking
Fluorescent Structural Tracking Channels
Real-time spatial-temporal tracking of functional genomic targets across selective sweeps. This channel tracks localization trajectories, cellular fusion boundaries, and protein self-organization mechanics under high magnification to pinpoint dynamic evolutionary fitness modifications.
This tracking interface lets us map structural trade-offs at single-cell resolution. Multi-channel fluorescent tracking reveals how cells reorganize genetic packages under real-time selection pressure.
Gaowen Liu Lab 